Arginine racemization by coupled catabolic and anabolic dehydrogenases
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چکیده
منابع مشابه
Arginine racemization by coupled catabolic and anabolic dehydrogenases.
D-amino acids exist in living organisms as specialized components of many different machineries. Biosynthesis of D-amino acids from racemization of predominant L-enantiomers is catalyzed by a single enzyme. Here, we report the finding of a novel 2-component amino acid racemase for D-to-L inversion in D-arginine metabolism of Pseudomonas aeruginosa. From DNA microarray analysis, the putative dau...
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Arginine racemase from Pseudomonas graveolens is inactivated by preliminary incubation with Lor D-ornithine, 6-Nacetyl-L-ornithine, and L-2,4-diaminobutyrate at pH 10.0. Loss of the enzyme activity is associated with formation of a new spectrum with an absorption maximum in the region of 320 rnp and disappearance of a peak at 420 mp. The inactivation is prevented, and the inactivated enzyme is ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2009
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0808269106